Klimov V, Klimov A, Koshkarova N. Autonomous Breakdown of the Allergen Tolerance in the Nose: A Hypothesis. Explor Res Hypothesis Med. Published online: Jun 24, 2022.Allergen tolerance is an active physiological process, which runs opposite to the adaptive immune response. The induction of allergen tolerance involves the multiple regulatory networks of cells and biomolecules. There are T regulatory cells, tolerogenic dendritic cells, IL10, IL35, TGFb, and immunosuppressive neurotransmitters. of this review is the overview of allergen tolerance mechanisms and its breakdown at the systemic and local levels, particularly concerning such specific organ as the nose. In this review, immune tolerance is initially considered on the whole. Then the review focuses on mechanisms of the physiological induction of allergen tolerance throughout the body, and pathogenesis of allergen tolerance breakdown with particular emphasis on both systemic and autonomous starting-off, taking into account two diverse entities (endotypes) of allergic rhinitis. Recently, two diverse endotypes, classical (conventional) allergic rhinitis and local allergic rhinitis, have been recognized. Although local allergic rhinitis revealed a decade ago, its immunopathogenesis is partially unclear, and a proper therapeutical protocol is not eventually developed. The possible role of neurotransmitter imbalance during the pathogenesis allergen tolerance breakdown is discussed. Accordingly, we proposed the hypothesis of autonomous allergen tolerance breakdown in local allergic rhinitis.

Keywords:   food allergens; sensitization routes; allergic rhinitis; asthma; food allergy The full names of authors :(1) Vladimir V. KLIMOV1, PhD, ScD, MD, Prof., e-mail: [email protected];ORCID iD 0000-0001-6673-7556;(2) Andrew V. KLIMOV1,2, PhD, MD, Assoc. Prof., e-mail: [email protected];ORCID iD 0000-0002-2776-5834.The author’s institutional affiliations :1 Immunology & Allergy Department, Siberian State Medical University, 2 Moscowsky tr, Tomsk, 634050, Russia;2 ENT Department, Siberian State Medical University, 2 Moscowsky tr, Tomsk, 634050, Russia.Author for correspondence: Vladimir V. KLIMOV, postal address: 28 Vershinin Str, Ap. 5, Tomsk, 634041, Russia; e-mail: [email protected]