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The Association between Elevated Carotid Intima-Media Thickness (CIMT) and Serum Uric Acid Levels among Patients with Essential Hypertension in Primary Care Setting.
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  • Mohd Zulhilmie Mohd Nasir,
  • Khasnur Abd MalekOrcid,
  • Mohamad Rodi Isa,
  • Mohd Farhan Hamdan,
  • Roqiah Fatmawati Abdul Kadir,
  • Fauziah Ahmad,
  • Wan Farzihan Wan Adib
Mohd Zulhilmie Mohd Nasir
Universiti Teknologi MARA
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Khasnur Abd Malek
Orcid
Universiti Teknologi MARA
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Mohamad Rodi Isa
Universiti Teknologi MARA
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Mohd Farhan Hamdan
Universiti Teknologi MARA
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Roqiah Fatmawati Abdul Kadir
Universiti Teknologi MARA
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Fauziah Ahmad
Ministry of Health Malaysia
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Wan Farzihan Wan Adib
Ministry of Health Malaysia
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Peer review status:POSTED

15 Jul 2020Submitted to International Journal of Clinical Practice
15 Jul 2020Assigned to Editor
15 Jul 2020Submission Checks Completed

Abstract

Aims: Our study aimed to investigate the relationships between elevated carotid-intima media thickness (CIMT) and serum uric acid (SUA) levels in hypertensive patients attending primary care clinics. Methods: We conducted a cross-sectional study on 140 hypertensive patients attending out-patient follow-up in two primary care clinics in Sungai Buloh, Malaysia, using a convenient sampling method. Serum uric acid levels were measured and divided into 4-quartile. Two radiologist specialists performed B mode ultrasonography to assess the right and left CIMT in all participants. Results: Participants’ mean SUA level was 355.75 ± 0.13. Their mean age was 53.44 (± 9.90), with a blood pressure control of 137.09 ± 13.22 / 81.89 ± 8.95. Elevated CIMT taken at ≥75th percentile was 0.666 for the left and 0.633 for the right common carotid arteries. Using multiple logistic regression, compared with the first quartile of the SUA level, the odd of elevated CIMT in quartile four in the common carotid artery was (OR=2.00; 95% CI= 0.64-6.27, p=0.576) for the right and (OR=0.62; 95% CI= 0.20-2.00, p=0.594) for the left. Waist circumference (p = 0.001), body mass index (p=0.013), triglycerides (p<0.001) and high-density lipoprotein cholesterol (p=0.001) were significantly associated with the SUA quartiles. Conclusion: Although there was an increasing trend in the odd of elevated right CIMT across the SUA quartiles, this association, however, was not significant. Preventive effort to tackle the clustering effect of metabolic markers within this study population is needed to reduce the future risk of developing cardiovascular disease.