Objective The aim of this study was to evaluate the effect of preoperative anxiety on depth of anesthesia and IVF success. Design Population-based cohort study. Setting Trakya University Population or Sample 131 patients between 25 and 43 years of age who were scheduled for oocyte retrieval under sedation. Methods The patients were divided according to Beck Anxiety Inventory (BAI): patients without anxiety were enrolled in the low-anxious group (Group L) and patients with anxiety were included in the high-anxious patient group (Group H). Hemodynamic stability, fertilization rate and good quality embryo (GQE) rate were recorded. Total propofol and fentanyl consumption was assessed intraoperatively. Main Outcome Measures Depth of anesthesia and IVF success Results The fertilization rate and GQE rate were not significant between the group L and group H. Total propofol consumption was significantly higher in group H than in groups L. The Heart rate (HR) at preoperative and postoperatively and systolic arterial pressure (SAP) at preoperatve and diastolic arterial pressure (DAP) at postoperative were significantly increased in groups H than in group L. The time for Modified Aldrete score (MAS) to reach 9 was significantly increased in group H than in group L. The effect of variables that were found significantly in the univariate analysis (Propofol, HRpreop, HRpostop, SAPpreop, DAPpostop, and MAS reach of time 9) on BAI score. Conclusions Total propofol consumption was higher in the high level of anxiety patients, but it was not have negative effect on IVF success. Funding Project by the Trakya University

Background: The association between arginase I (ARG1) and arginase II (ARG2) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are unknown. Objective: To examine the association between genetic variation in ARG1 and ARG2 genes and PSW phenotypes and to compare results with asthmatic patients. Methods: We enrolled 102 patients and 86 healthy controls. The patient group included three subgroups: episodic wheezing (EW) (n = 42, median age 41 months), multiple-trigger wheezing (MW) (n = 41, median age 39 months), and asthma (n = 19, median age 72 months). We genotyped six single nucleotide polymorphisms (SNPs) in ARG1 and six SNPs in ARG2. Eighteen haplotypes for ARG1 and 31 haplotypes for ARG2 were constituted, and the distributions of SNPs and haplotypes in patients and controls were analyzed. Results: The frequency of homozygote cytosine-cytosine genotype of the ARG1 rs2781667T>C SNP in the EW group was significantly lower than controls (p = 0.006) [OR (95% CI): 0.26 (0.10-0.66)], the MW group (p = 0.002) [OR (95% CI): 0.19 (0.06-0.52)], and asthmatics (p = 0.025) [OR (95% CI): (0.22 (0.06-0.75)]. ARG1 haplotype 4 was more frequent in the MW group, asthmatics, and controls than in the EW group (p < 0.0001) [OR (95% CI): 7.77 (2.54-23.7)], (p = 0.036) [OR (95 %CI): 4.31 (1.15-16.15)], and (p = 0.030) [OR (95% CI): 3.44 (1.20-10.0)]. Conclusion: Variations in ARG1 gene may be useful in discriminating PSW phenotypes.