In this study, psychosocial impact of coronavirus lockdown on Nigerians was assessed through a cross-sectional descriptive survey across the 36 States and Federal Capital Territory in Nigeria. The survey comprised a sample of 740 adults (54.32% male and 45.68% female). The 3 psychosocial metrics investigated were depression, stress and anxiety. Data obtained in the survey were analysed using the descriptive (percentages and frequency) and inferential (test for association using chi-square trend test-Cochran-Armitage trend) statistics. Findings showed that coronavirus lockdown had a psychosocial impact on Nigerians, particularly on mental wellbeing as agreed upon by 50% of respondents. While the lockdown was established to have ushered in symptoms of anxiety and depression, educational level and religion were statistically significant in association with depression at χ 2 = 11.510, p-value = 0.0007 and χ 2 =8.3419, p-value = 0.0039 respectively. Cases of domestic violence with emphasis on rape increased due to frustration, idleness and inaccessibility to sex commercial workers. Based on these findings, it is concluded that coronavirus lockdown had a psychosocial impact on Nigerians. Therefore, it is recommended that Nigerian governments should put more stringent measures aimed at containing these social vices, by proactively engaging law enforcement agencies to prosecute those that violate curfew hours. Again, the government should devise other measures of involving citizens in proactive activities that could disengage them from inexplicable behavioural patterns; this would enable them develop the right attitude for positive mental wellbeing.