Abstract Background: Epidemiologic studies have reported that dietary acid load is associated with psychological disorders through different pathways. We aimed to examine the association of dietary acid-base load with Psychological Disorders, Sleep and circadian rhythm. Methods: This study was performed on 404 female subjects ≥18 years old. We evaluated potential renal acid load (PRAL), net endogenous acid production (NEAP) score by a valid food frequency questionnaire (FFQ) for Iran of with 147 items. To assess psychological disorders, an Iranian validated version of depression, anxiety, and stress scale (DASS-21) was used. The Pittsburgh Sleep Quality Index (PSQI) and morning-evening questionnaire (MEQ) were applied to evaluate sleep quality and circadian rhythm status respectively. Results: Considering a wide range of confounding variables, compared with the low adherence, a significant positive association was observed between dietary acid-base load and severe depression (OR PRAL =1.10, 95%CI=1.01-1.19, P=0.02) and (OR NEAP =2.46, 95%CI=1.41-14.61, P=0.02). Women in the high dietary acid base load category had higher anxiety (ORPRAL=1.12,95%CI=1.02-1.23, P=0.01) and (ORNEAP=1.80,95%CI=1.12-10.72, P=0.01). There was a strong positive relationship between dietary acid-base load and sleep disturbance (P<0.05). Additionally, circadian rhythm assessment showed that those with greater commitment to PRAL had 23% higher risk of being completely E-type, while odds of being completely M-type, was decreased by 15% and 12% across higher adherence to PRAL and NEAP. Conclusion: Women with higher dietary acid-base load score had greater odds for depression, anxiety, psychological distress, sleep disturbance and circadian rhythm compared to lower ones.

Abstract Aim: Oxidative stress represents a cornerstone of a wide range of chronic diseases. Studies have identified an inconsistent effect of green tea on regulating oxidative stress. We aimed to examine the evidence from randomized clinical trials (RCTs) to assess the effects of green tea on oxidative stress markers including malondialdehyde (MDA), and total antioxidant capacity (TAC) in adults. Methods: A systematic search of English language publications in PubMed, Scopus and Embase was performed up to September 1, 2020. Data were pooled using the random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Results: Fourteen RCTs met inclusion criteria. There was a significant relationship between green tea and TAC. Our results indicated that green tea had significant effects on TAC (weighted mean difference [WMD]: 0.18; 95 % CI, 0.07, 0.29, P =0.001) and significant heterogeneity between studies (I2 = 98.6%, p <0.001) which was largely related to sex and BMI. Subgroup analysis in TAC identified a significant relationship except in low dose and obese individuals. No relationship between MDA and green tea was observed overall and in all subgroups. Conclusions: We found that the intervention with green tea significantly increased the TAC, while, it had no significant effect on MDA. Key Words: green tea, oxidative stress, total antioxidant capacity, malondialdehyde.

Background: Obesity is a global issue. Energy density (ED) can influence on body compositions (BCs). Consumption of HED (high energy density) foods can increase body fat mass (BFM) and inflammatory markers. Methods: This study was a cross-sectional research among 391 women. Body composition analyzer (BIA) and food frequency questionnaire (FFQ) was used to assess BCs and food intake of individuals. Blood samples and serum level of high-sensitive C-reactive protein (hs-CRP), plasminogen activator inhibitor- 1 (PAI-1) and transforming growth factor-β (TGF-beta) were collected. ED per one gram of foods were calculated and divided to quartiles. Linear logistic regression tests were used to investigate the association between BCs across quartiles of ED intake. Results: Results demonstrate skeletal muscle mass (SMM), total body water (TBW), intracellular water (ICW), fat free mass (FFM), visceral fat area (VFA) and fat free mass index (FFMI) was seem to be under the effect of hs-CRP among ED intakes. TBW, extracellular water (ECW), FFM with PAI-1, bone mineral content (BMC) with PAI-1 and TGF-beta, and Skeletal lean mass (SLM) with hs-CRP were inversely associated. Fat right arm (FRA), fat right arm (FLA), fat right and left leg (FRL,FLL), fat trunk, TBW, ICW, ECW, BFM, FFM, SMM, SLM, waist circumference (WC), FFMI and FMI were positively under the influence of TGF-beta after following higher ED food intakes. FRA, FLA, FRL, FLL, fat trunk, ICW, BFM, SMM, SLM, WC, FFMI and FMI were positively under the influence of PAI-1. Conclusion: All adipose tissue content of subcategories of BC were strongly associated with ED intake in the mediatory role of PAI-1 and TGF-beta.

Background: Metabolic syndrome (MetS) is related with all-cause mortality. Caveolin-1 (Cav-1) has been widely studied in dyslipidemia, and several studies have indicated that Cav-1 genetic variations may correlate with dietary intake of fatty acids. The aim of the current study was therefore to evaluate the interaction of Cav-1 rs3807992 with types of dietary fatty acid in MetS risk factor status Methods: This cross-sectional study was carried out on 404 overweight and obese females. Dietary intake was obtained from a 147-item FFQ. The CAV-1 genotype was measured using the PCR-RFLP method. Anthropometric values and serum levels (TC, LDL, HDL, TG, FBS) were measured by standard methods. Results: It was observed that the (AA+AG) group had significantly higher BMI, WC and DBP (P=0.02, P=0.02 and P=0.01, respectively) and lower serum LDL, HDL and TC (P < 0.05) than the GG group. It was found that A allele carriers were at higher odds of MetS (P= 0.01), abdominal obesity (P=0.06), increased TG concentration (P=0.01), elevated blood pressure (BP) (P=0.01), increased glucose concentration (P=0.45), and decreased HDL-cholesterol concentration (P=0.03). Moreover, the interaction of Cav-1 and SFA intake was significant in terms of MetS (P=0.01), LDL (P=0.03), DBP (P=0.01) and LDL/HDL (P=0.05). Additionally, the (AA+AG) group was significantly related to PUFA intake in terms of MetS (P=0.04), TG (P=0.02), glucose (P=0.02) and HOMA-IR (P= 0.01). Conclusions: Higher PUFA consumption might attenuate the Cav-1 rs3807992 associations with MetS, and individuals with greater genetic predisposition appeared to have a higher risk of MetS, associated with higher SFA consumption To date, studies on this polymorphism have been animal studies and have not been performed on healthy and obese human society For the first time , this study provides information on the interaction of different fatty acids with the Caveolin gene, which is functionally effective in lipid metabolism