Xiang-Fei Feng

and 5 more

Aims The left atrial appendage (LAA) is one of the major sources of atrial tachycardias (ATs) in children. However, endocardial ablation in LAA may fail or even cause fatal tamponade; and epicardial ablation with subsequent surgical appendectomy (SAE) may be required. There is no relevant report in children. We aimed to evaluate the feasibility of epicardial ablation with SAE in children. Methods and results The epicardial ablation with SAE was performed in a 12-year-old girl with an incessant AT. Endocardial mapping demonstrated endocardial activation time of −112 msec and −105 msec (relative to the onset of the A wave at CS9-10) in the right ventricular outflow tract and LAA, respectively. But multiple ablation attempts at these sites did not terminate the AT. After the left-side pericardium opened, the earliest activation (−120 msec) during AT was found at the apex of upper lobe. At this site, ablation eliminated the tachycardia within 5 seconds of onset of energy. After ablation, the LAA was excited, followed by a continuous over and over suture to definitely close the resection line. The free of AT and a decrease in LAD and NT-proBNP were achieved during the 12-month follow-up. Conclusion The epicardial ablation with subsequent SAE was successfully performed in a child. The heart function of the patient improved after a 12-month follow-up. The excision of LAA may be an ideal strategy for children with incessant AT originating from epicardial LAA. However, the long-term safety and efficacy of SAE in children should be further estimated.

Xiang-Fei Feng

and 7 more

Introduction: Cardiac resynchronization therapy via biventricular pacing is an established therapy for patients with heart failure. However, high nonresponder rates and inability to predict response remains a challenge. Recently left bundle branch area pacing (LBBAP) has been shown to be feasible and may also improve clinical outcomes. In this article we describe sequential LBBAP followed by left ventricular (LV) pacing (LOT-CRT) and assess the feasibility of LOT-CRT. Methods: The RV implantation site was positioned and the LBBAP lead was implanted using our methods. The QRS duration (QRSd) at baseline, during LBBAP, biventricular pacing, and LOT-CRT was measured. Results: LOT-CRT was successful in 5 patients (age 71.8 ± 5.1 years, men 3, ischemic 3). The QRSd at baseline was 158.0 ± 13.0 ms and significantly narrowed to 117.0 ± 6.7 ms during LOT-CRT (P < 0.01). During 3-month follow-up, LV ejection fraction improved from 32.8 ± 5.2 % to 45.0 ± 5.1% (P < 0.01), and New York Heart Association functional class changed from 3.25 ± 0.5 to 2.5 ± 0.6 (P < 0.05). A decrease in left ventricular end-diastolic dimension was observed, with widening from (68.2 ± 12.3) mm at baseline to (62.2 ± 11.3) mm at pacing (P < 0.05). The length of operation time was (152.0 ± 31.1) min. Conclusions: The study demonstrates that LOT-CRT is clinically feasible in patients with systolic HF and LBBB. LOT-CRT was associated with significant narrowing of QRSd and improvement in LV function, especially in patients with ischemic cardiomyopathy.