Aims: Premature ejaculation (PE) is a common sexual dysfunction that significantly affects the quality of life of the patient and their partner. We aimed to compare efficacy and safety of the combination therapy with biofeedback-guided pelvic floor exercise therapy (BFT) and dapoxetine 30 mg. Results: Patients were divided into three groups as BFT, dapoxetine 30 mg and combination with BFT and dapoxetine 30 mg. The patients were compared with the intravaginal ejaculatory latency time (IELT) pre-treatment and post-treatment 1st and 3rd months. The mean IELTs of the patients in Group 1 were 40 sec in pre-treatment, 115 sec at the end of the 4th week and 140 sec at the end of the 12th week. The IELT values of the patients in Group 2 were 40 sec in pre-treatment, 145 sec in the 4th week and 170 sec in the 12th week . The IELT values were calculated in Group 3 as 42.5 sec in pre-treatment, 185 sec in the 4th week and 205 sec in the 12th week When the IELT was statistically compared between the groups at 1st and 3rd months, the duration in combination group was found to increase significantly (p < 0.001). Discussion: Pelvic floor muscles play an important role in sexual function. Rehabilitation of pelvic floor muscles provides two-stage efficiency with electrostimulation and physiokinesitherapy; it aims to improve the contractile forces of the perineal muscles and increase the urethral sphicter closure force. Besides, the rehabilitation of pelvic floor muscles allows patients to control the contractions of the right muscle group accompanied by biofeedback Conclusion: Combination therapy with BFT and dapoxetine 30 mg in lifelong PE treatment is a good alternative with low side effect profile and acceptable continuous efficiency

Purpose: The aim of this study is to analyze the preoperative and intraoperative factors that might induce systemic inflammatory response syndrome after semirigid ureteroscopic lithotripsy (SULL) , and to evaluate the impact of duration between preoperative bladder urine culture (PBUC) and surgery on postoperative systemic inflammatory response syndrome (SIRS). Methods: A retrospective review was conducted including patients who underwent SULL in our center between January 2011 and June 2020. Prior to surgery, PBUC were obtained from all patients and postoperatively patients were observed for signs of SIRS. Univariable and multivariable binary logistic regression analysis were implemented to demonstrate the factors that predict SIRS postoperatively. Results: The entire study included a cohort of 572 patients. The rate of SIRS following SULL was 1.7%. Predictive factors for SIRS were listed as stone volume, surgical time, and history of recurrent urinary tract infection. No significant difference was detected in terms of the duration between PBUC and SULL when comparing the SIRS group with the other group. Conclusion: The duration between PBUC and SULL is not an efficacious factor for SIRS. It may be useful to conduct prospective studies to enlighten this issues as endourologists deal with this duration dilemma often in daily practice. Keywords: Semirigid ureteroscopic lithotripsy, Systemic inflammatory response syndrome, Preoperative bladder urine culture