Role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in
sepsis and sepsis mortality: A Meta-Analysis
Abstract
Background: Sepsis is the most common health problem because of which an
increased proportion of health resources are consumed. Tumour Necrosis
factor alpha also plays an essential role in many diseased conditions
like diabetes, cancer, etc. There have been findings suggesting a high
level of correlation between TNF activity and sepsis susceptibility and
mortality. Thus, the present meta-analysis was carried out to assess the
role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in
sepsis and sepsis mortality. Methods: The meta-analysis was carried out
using the MOOSE guidelines. A total number of 782 articles were
retrieved, out of which only 45 full-text articles were eligible. Out of
that, 24 were used for meta-analysis after checking the quality of
articles. The meta-analysis was carried out using MedCalc Software. The
comparison of TNF factor alpha 1 and 2 among patients was calculated in
the two groups. The odds ratio of these studies was used to construct
the forest plot. Results: Eight studies evaluated the odds of having
increased TNF1 in sepsis conditions. The plot shows that the cumulative
statistics are significant at a 95% confidence level and have a p-value
less than 0.05. The odds of increased TNF2 in sepsis conditions among
Asians is more than in the case of TNF1. The odds ratio of 0.978
indicates that the odds of increased TNF1 in sepsis conditions among
Caucasians are more than in the case of TNF2. Conclusion: The
meta-analysis suggests an association between the G/A allele combination
of TNF-α and sepsis risk in the Asian population compared to the
Caucasian Population.