Tacrolimus-Induced Systemic Drug Related Intertriginous and Flexural
Exanthema after Hematopoietic Stem Cell Transplantation
Abstract
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE),
previously known as “Baboon Syndrome,” is diagnosed if four or more of
the following criteria are met: symmetry, involvement of at least one
intertriginous zone, erythema of the gluteal, inguinal, or axillary
region, systemic exposure to a drug, and lack of systemic toxicity. A
first ever case of SDRIFE after HSCT is presented who was initially
treated for multiple recurrences of acute skin graft versus host
disease. SDRIFE should be considered in the differential diagnosis of
refractory GvHD and is easily treatable by avoiding the offending
medication