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Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block
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  • Yuichi Nakamura,
  • Yoshihiro Itoh,
  • Naoki Wakimoto,
  • Ryu Kanno,
  • Shinichirou Iida,
  • Keiji Yamamoto
Yuichi Nakamura
Saitama Medical University

Corresponding Author:[email protected]

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Yoshihiro Itoh
Saitama Medical University
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Naoki Wakimoto
Saitama Medical University
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Ryu Kanno
Saitama Medical University
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Shinichirou Iida
Saitama Medical University
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Keiji Yamamoto
Saitama Medical University
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Abstract

Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome.
14 Nov 2022Submitted to Clinical Case Reports
14 Nov 2022Submission Checks Completed
14 Nov 2022Assigned to Editor
10 Dec 2022Reviewer(s) Assigned
23 Dec 2022Review(s) Completed, Editorial Evaluation Pending
06 Jan 2023Editorial Decision: Revise Minor
08 Jan 20231st Revision Received
11 Jan 2023Submission Checks Completed
11 Jan 2023Assigned to Editor
11 Jan 2023Review(s) Completed, Editorial Evaluation Pending
06 Feb 2023Editorial Decision: Accept