Significance of dynamically monitoring serum estrogen and β-human
chorionic gonadotropin in early pregnancy assessment
Objective: To investigate the clinical significance of dynamically
monitoring serum estradiol (E2) and β-human chorionic gonadotropin
(β-HCG) in early pregnancy assessment and their values in predicting
pregnancy outcomes.. Methods: In this retrospective study, two hundred
early pregnancy women were divided into two groups according to their
early pregnancy outcomes: the ongoing pregnancy group and inevitable
abortion group. Serum E2 and β-HCG levels and their growth rates were
compared weekly. Results: E2 and β-HCG of the ongoing pregnancy group
were significantly higher than that of the inevitable abortion group
from the 5th to 10th week of pregnancy. Taking 489.5 pg/ml in the 5th
and 6th week, 590.5 pg/ml in the 7th week and 614.5 pg/ml in the 8th
week as cut-off levels of E2, the sensitivity and specificity for E2 to
predict bad pregnancy outcome were 91.7% and 41.5%, 82.9% and 71.1%,
84.8% and 84.7%, 75.0% and 95.7%, respectively (P< 0.05).
Both E2 and β-HCG increased much more rapidly in the ongoing pregnancy
group. 80% of the normal pregnancy women showed continuously increasing
E2 level. Meanwhile, the inevitable abortion group presented E2
variation types as slow increase or fluctuation, continuous decline, and
sudden drop, which account for 54.0%, 34.0%, and 12.0%, respectively.
Conclusion: Low values and low growth rates of E2 and β-HCG probably
indicate bad pregnancy outcomes.