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Parosmia is associated with relevant olfactory recovery after olfactory training
  • +4
  • David Liu,
  • Maha Sabha,
  • Michael Damm,
  • Carl PhilpottOrcid,
  • Anna Oleszkiewicz,
  • Antje Haehner,
  • Thomas Hummel
David Liu
Dresden University of Technology
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Maha Sabha
Dresden University of Technology
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Michael Damm
University Hospital Cologne
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Carl Philpott
Orcid
University of East Anglia, University of East Anglia
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Medium
Anna Oleszkiewicz
Dresden University of Technology
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Antje Haehner
Dresden University of Technology
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Thomas Hummel
Dresden University of Technology
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Peer review status:UNDER REVIEW

12 May 2020Submitted to Clinical Otolaryngology
13 May 2020Submission Checks Completed
13 May 2020Assigned to Editor
01 Jun 2020Review(s) Completed, Editorial Evaluation Pending
05 Jun 2020Editorial Decision: Revise Minor
05 Jun 20201st Revision Received
08 Jun 2020Submission Checks Completed
08 Jun 2020Assigned to Editor
19 Jun 2020Reviewer(s) Assigned

Abstract

Objectives This study aims to determine the association between parosmia and clinically relevant recovery in olfactory function in patients with smell loss receiving olfactory training. Design and setting This was a retrospective cohort study of patients that received olfactory training. Adult patients with the major complaint of quantitative smell loss were recruited and treated at several ENT clinics in German between 2008 and 2018. Participants A total of 243 participants were included. Main outcome measures Changes in olfactory function after olfactory training. Age, gender, baseline olfactory function, etiology and duration of smell loss, duration of training, and presence of parosmia and phantosmia were assessed for their impact on clinically relevant changes in overall and subdimension olfactory function using binary logistic regression analysis. Results Relevant improvements in discrimination function were more likely in those that had lower baseline olfactory function, postinfectious reasons compared to posttraumatic or idiopathic causes and those that had parosmia at initial visit. Relevant improvements in odour identification were more likely in those that had a lower baseline olfactory function, female gender, and in those who had parosmia at the first visit. Clinically significant improvements in odour threshold were more likely in postinfectious causes compared to posttraumatic reasons and those who were older in age. Conclusions This study demonstrated that the presence of parosmia is associated with clinically relevant recovery in olfactory function in patients with smell loss receiving olfactory training.