Background: Sepsis is the most common health problem because of which an increased proportion of health resources are consumed. Tumour Necrosis factor alpha also plays an essential role in many diseased conditions like diabetes, cancer, etc. There have been findings suggesting a high level of correlation between TNF activity and sepsis susceptibility and mortality. Thus, the present meta-analysis was carried out to assess the role of Tumour Necrosis Factor-Alpha promoter 308A/G polymorphism in sepsis and sepsis mortality. Methods: The meta-analysis was carried out using the MOOSE guidelines. A total number of 782 articles were retrieved, out of which only 45 full-text articles were eligible. Out of that, 24 were used for meta-analysis after checking the quality of articles. The meta-analysis was carried out using MedCalc Software. The comparison of TNF factor alpha 1 and 2 among patients was calculated in the two groups. The odds ratio of these studies was used to construct the forest plot. Results: Eight studies evaluated the odds of having increased TNF1 in sepsis conditions. The plot shows that the cumulative statistics are significant at a 95% confidence level and have a p-value less than 0.05. The odds of increased TNF2 in sepsis conditions among Asians is more than in the case of TNF1. The odds ratio of 0.978 indicates that the odds of increased TNF1 in sepsis conditions among Caucasians are more than in the case of TNF2. Conclusion: The meta-analysis suggests an association between the G/A allele combination of TNF-α and sepsis risk in the Asian population compared to the Caucasian Population.